Mediators in the Cardiovascular System: Regional Ischemia

Abstract

Prostaglandins and related eicosanoids.- Regulation of prostanoid-synthesis in the cardiovascular system.- Molecular regulation and augmentation of prostacyclin biosynthesis.- Testosterone regulation of platelet and vascular thromboxane A2 receptors.- Formation of 8-iso-prostaglandin F2? by human platelets.- Regulation of prostaglandin receptors in myocardial ischemia.- Hydroxylated 22-carbon fatty acids in platelet and vascular smooth muscle function: Interference with TXA2/PGH2 receptors.- Increased permeability of bovine aortic endothelial cell monolayers in response to a thromboxane A2-mimetic.- Potentiation of PDGF-induced growth responses in coronary artery smooth muscle cells by thromboxane.- The induction of cyclooxygenase-2 elicited by endotoxin in endothelial cells and macrophages is inhibited by prostaglandin E1 and 13,14-dihydro prostaglandin E1.- Effects of prostaglandin E1, prostaglandin E0 and SPM 206 on isolated human coronary arteries.- Vasodilator effects of PGE1 in the coronary and systemic circulation of the rat are mediated by ATP-sensitive potassium (K+) channels.- Diminished inhibition of adhesion molecule expression in prostacyclin receptor desensitized human platelets.- Iloprost-induced inhibition of proliferation of coronary artery smooth muscle cells is abolished by homologous desensitization.- The cardioprotective actions of iloprost in myocardial ischemia of the rabbit can be separated from its vasodilatory effects mediated by KATP+-channel opening.- Cicaprost inhibits collagen-induced platelet accumulation in rat lungs for some hours..- Nitric oxide.- The endothelial cell nitric oxide synthase: Is it really constitutively expressed?.- Kinin-mediated activation of endothelial nitric oxide formation: Possible role during myocardial ischemia.- Metabolism and excretion of nitric oxide in man: Basal studies and clinical applications.- Nitric oxide mediates microvascular permeability in the isolated perfused rat mesentery?.- Interplay of nitric oxide and histamine in the regulation of coronary reactive hyperemia and coronary autoregulation.- Exogenously supplied nitric oxide influences the dilation of the capillary microvasculature in vivo.- Effects of prolonged L-arginine administration on blood pressure in patients with essential hypertension (EH).- A neutrophil-derived nitric oxide-synthase (NOS) inhibitor.- Elevation of circulating nitric oxide: Its effects on hemodynamics and vascular smooth muscle cell proliferation in rats.- Activation of endothelial guanylate cyclase inhibits cellular reactivity.- Nitric oxide - related drugs.- Comparison of the vasorelaxing effect of different nitrovasodilators in conductive arterial and venous blood vessels.- Glyceryl trinitrate but not spontaneous nitric oxide donors preserve myocardial function and cell integrity in ischemic rabbit hearts.- Effects of nitric oxide donors, SIN-1 and GEA 3175 on prostacyclin and cGMP synthesis in cultured rat endothelial cells.- Effects of pentaerythrityl-tetranitrate and isosorbide-5-mononitrate in experimental atherosclerosis.- Effect of nitric oxide donors on rat bronchial muscle in vitro.- Rapid tolerance to formation of authentic nitric oxide from nitroglycerin in vivo.- The exercise-induced increase in plasma levels of endothelin-1 is enhanced in patients with atherosclerotic coronary artery disease. Modulation by pentaerithrityltetranitrat (PETN).- Vasoactive peptides and lipid mediators.- Clinical relevance of endothelial dysfunction in cardiovascular disorders.- Endothelin and endothelin antagonists: Pharmacology and clinical implications.- Platelet-vessel wall interactions, focal adhesions, and the mechanism of action of endothelial factors.- The effects of intracellular Ca2+ concentration and hypoxia on basal endothelin-1 secretion by cultured porcine aortic endothelial cells.- The similarity in action of hypoxia and platelet-activating factor on smooth muscle cells of coronary arteries: Possible explanation for hypoxic coronary spasm development.- Pituitary adenylate cyclase activating peptides are endothelium-independent dilators of human and porcine coronary arteries.- Coupling of hepoxilin A3-specific binding with calcium-mobilizing actions in human neutrophils.- Role of intracellular calcium in the regulation of phospholipase A2 in fMet-Leu-Phechallenged human polymorph neutrophils.- Thrombin receptor activating peptide - induced cellular effects: Comparative studies on human platelet activation and endothelium-dependent relaxation of porcine pulmonary arteries.- Inositol 1,4,5-triphosphate and protein kinase C are involved in thrombin and TRAP-induced vascular smooth muscle contraction.- Isolation and functional characterization of DNA-derived aptamers that act as thrombin inhibitors in human platelets and coagulation assays.- Defibrotide's activity on leukocytes and platelets in rabbits with diet-induced atherosclerosis.- Author Index.- Keyword Index.