Mediated release of glutamate and GABA by cathodic reduction of cobalt complexes

Abstract

The electrochemical reduction of cobalt (III) complexes containing the neurotransmitter GABA or GLU as ligands were investigated using aqueous solutions as a model sytem for drug release. The release of the neurotransmitter was found to be efficient. In one case the reduction proceeded directly, in another it was mediated by methyl viologen. The kinetic of the catalyzed process were analyzed using electrochemical techniques. In addition, unusual trace crossings in the cylic voltammograms of the catalytic system, as well unusual chronoamperometric curves, were observed. These phenomena wwere attributed to the electrodeposition of cobalt metal.