Abstract
In many centers, laparotomy and splenectomy is an important procedure in the staging and management of Hodgkin's disease patients. Surgery usually is performed under general anesthesia with endotracheal intubation. Acute complications of such anesthesia in patients with mediastinal disease prompted a review of the anesthesia experience for any procedure in all Hodgkin's disease patients seen at our center from April 1969 through December 1973. Acute life-threatening complications occurred in 5 of 74 intubation anesthesias carried out in untreated patients with mediastinal and/or hilar disease; no complications were seen in 24 anesthesias performed after radiation therapy of mediastinal disease, or in 78 anesthesias in patients without intrathoracic disease. The incidence of anesthesia complications was related to mediastinal mass size. Hodgkin's disease patients with significant mediastinal masses should be treated before surgery whenever possible.
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