Medial temporal neuroinflammation unleashes tau spreading over the neocortex

Abstract

AbstractBackgroundTransentorhinal tau neurofibrillary tangles deposition is a typical finding in cognitively unimpaired (CU) elderly. Thus, how tau tangle spreads over the neocortex, leading to disease progression, is a pressing issue in Alzheimer's disease (AD). Although amyloid is postulated to trigger this spread, the fact that amyloid deposition is present in low concentrations in temporal structures challenges this framework. Here, we tested the hypothesis that brain amyloid burden interacts with medial temporal neuroinflammation unleashing tau spread over the neocortex. To assess neuroinflammation, we used [11C]PBR28 PET, a ligand that binds to the 18‐kDa translocator protein(TSPO), considerate a proxy of inflammation.MethodsTSPO polymorphism (rs6971) was genotyped in 678 participants from the Montreal catchment area (48% presented rs6971 polymorphism of high TSPO binders). Following inclusion/exclusion criteria, we studied 131 high TSPO binders (22 CU young, 63 CU elderly, 28 MCI, 18 AD). All individuals had PET; amyloid [18F]NAV4694, tau [18F]MK6240, and [11C]PBR28,as well as MRI, cognitive and genetic assessments. Structural equation modeling (SEM) tested associations between markers.Results[11C]PBR28 uptake was progressively higher from CU to AD(Fig.1). [18F]NAV4694,[18F]MK6240, and [11C]PBR28 were correlated (Fig.2); however, analysis of variance suggested that an interaction between [18F]NAV4694and[11C]PBR28 on [18F]MK6240 best explain the association between these markers(P<0.0001). Voxel‐wise analysis, taking into consideration global and local tracer effects, suggests an interaction between global [18F]NAV4694 and medial temporal [11C]PBR28 on medial temporal [18F]MK6240(Fig.3). Stratified analysis revealed that individuals with abnormal amyloid, tau, and neuroinflammation (A+/T+/NI+) had elevated cognitive impairment and hippocampus atrophy(Fig.4). SEM suggests that global amyloid interacts with transentorhinal inflammation leading to tau spread over Braak II‐III(Fig.5). Subsequently, tau hierarchically spread from Braak III to VI. Models inverting the variables mentioned above or the order of Braak regions did not fit the data. Accumulation of tau only in Braak IV‐VI was associated with cognitive symptoms (Fig.6).ConclusionOur results suggest that an interaction between global amyloid and medial temporal neuroinflammation triggers tau spread over the neocortex. Global amyloid may represent distant amyloid load or amyloid oligomers. Our results suggest individuals with tau deposition confined to transentorhinal cortex as targets for the use of anti‐inflammatory drugs in AD.