Medial temporal lobe substructures differentially contribute to processing within- and between-domain associative recognition memory for semantic and non-semantic stimuli

Abstract

Event Abstract Back to Event Medial temporal lobe substructures differentially contribute to processing within- and between-domain associative recognition memory for semantic and non-semantic stimuli Marshall A. Dalton1, 2*, Michael Hornberger1, 2 and Olivier Piguet1, 2 1 Neuroscience Research Australia , Australia 2 School of Medical Sciences, University of New South Wales, Australia Introduction The domain dichotomy theory posits that medial temporal lobe (MTL) substructures differentially contribute to different types of associative memory processing with the hippocampus implicated in the integration of information from different perceptual or conceptual domains (between-domain [BD] memory processing) and the perirhinal cortex involved in within-domain (WD) memory processing. The aim of this study was to determine whether the neural correlates of recognition memory on WD and BD associative memory tasks differ when processing semantic and non-semantic stimuli. Methods Twenty healthy adults participated in an fMRI experiment comprising three associative memory tasks: (i) a WD task using non-semantic stimuli, (ii) a WD task using compound words, (iii) a BD task using a word-location paradigm. Results WD associative recognition memory for non-semantic stimuli correlated with an increased BOLD signal in the right perirhinal cortex. WD associative recognition memory for semantic stimuli correlated with an increased BOLD signal in the left anterior hippocampus. BD associative recognition memory correlated with an increased BOLD signal in the left posterior hippocampus. Conclusions Results of this study support the theory that MTL substructures differentially contribute to different types of associative memory processing and in addition show that MTL substructures also differentially contribute to associative memory processing of semantic and non-semantic stimuli. These results have important implications for theoretical models of associative and episodic memory processing in the human MTL. Acknowledgements This work was supported by the Australian Research Council [DP110104202 to M.H.] and the National Health and Medical Research Council of Australia [APP1022684 to O.P.]. M.A.D. is supported by an Australian Rotary Health award. Keywords: medial temporal lobe, Hippocampus, perirhinal cortex, Associative Memory, episodic memory Conference: ACNS-2012 Australasian Cognitive Neuroscience Conference, Brisbane, Australia, 29 Nov - 2 Dec, 2012. Presentation Type: Oral Presentation Topic: Memory Citation: Dalton MA, Hornberger M and Piguet O (2012). Medial temporal lobe substructures differentially contribute to processing within- and between-domain associative recognition memory for semantic and non-semantic stimuli. Conference Abstract: ACNS-2012 Australasian Cognitive Neuroscience Conference. doi: 10.3389/conf.fnhum.2012.208.00136 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 25 Oct 2012; Published Online: 17 Nov 2012. * Correspondence: Mr. Marshall A Dalton, Neuroscience Research Australia, Sydney, Australia, m.dalton@neura.edu.au Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Marshall A Dalton Michael Hornberger Olivier Piguet Google Marshall A Dalton Michael Hornberger Olivier Piguet Google Scholar Marshall A Dalton Michael Hornberger Olivier Piguet PubMed Marshall A Dalton Michael Hornberger Olivier Piguet Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.