Medial gastrocnemius growth in children who are typically developing: Can changes in muscle volume and length be accurately predicted from age?

Abstract

Muscle size is an important determinant of muscular fitness and health, and so it is important to have accurate estimates of actual muscle growth in children. This study compared actual versus age-predicted growth rates of the medial gastrocnemius (MG) muscle in young children over a 12-month period. Three-dimensional ultrasound was used to measure MG length and volume in 50 children (mean±standard deviation [SD] age=70.3±29.9months) to establish age-predicted muscle growth rates using a least-squares linear regression. Twenty children (mean±SD age=78.5±27.2months) were followed up at 6 and 12months to establish actual muscle growth of MG volume and length. These data were then compared to their age-predicted muscle growth from the linear regression equation using paired t-tests and Bland-Altman limits of agreement method. Age-predicted MG growth significantly underestimated actual muscle growth for both volume and length at each timepoint. On average, actual muscle volume and length were 11.5% and 21.5% greater than the age-predicted volume and length respectively. Caution is warranted when predicting future muscle size in young children based solely on age.