Abstract
Mechanotransduction is essential for cell fate and behavior, and F-actin plays a key role in the generation and transmission of molecular forces. A recent study published in Nature Communication presented a novel high-precision molecular tension measurement method using a Förster resonance energy transfer–based tension sensor with separated load-bearing function within distinct F-actin structures, and demonstrated that cellular mechanical anisotropy depends on cell shape, loading direction, and magnitude.
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