Abstract
Mechanical stimuli are required for the maintenance of skeletal integrity and bone mass. An increasing amount of evidence indicates that multiple regulators (e.g., hormone, cytoskeleton proteins and signaling pathways) are involved in the mechanical stimuli modulating the activities of osteogenic cells and the process of bone formation. Significantly, recent studies have showed that several microRNAs (miRNAs) were sensitive to various mechanical stimuli and played a crucial role in osteogenic differentiation and bone formation. However, the functional roles and further mechanisms of mechanosensitive miRNAs in bone formation are not yet completely understood. This review highlights the roles of mechanosensitive miRNAs in osteogenic differentiation and bone formation and underlines their potential therapeutic application for bone loss induced by the altering of mechanical stimuli.
Highlights
IntroductionAs a mechanical sensory organ, is constantly remodeled (bone formation and bone resorption) under a normal mechanical environment [1,2]
Bone, as a mechanical sensory organ, is constantly remodeled under a normal mechanical environment [1,2]
This review aims to provide an overview of the relationship between mechanosensitive miRNAs and bone formation, including mechanosensitive miRNAs and osteogenic differentiation; mechanosensitive miRNAs and osteoblast proliferation; and mechanosensitive miRNAs and bone formation
Summary
As a mechanical sensory organ, is constantly remodeled (bone formation and bone resorption) under a normal mechanical environment [1,2]. Post-natal bone formation is controlled by osteogenic cells, which are believed to be responsive to different mechanical stimuli [3,4]. Previous reports from our laboratory and others have demonstrated that multifactorial regulators are involved in the mechanical stimuli modulating the activity of osteogenic cells and bone formation, such as hormones or cytokine (e.g., parathyroid hormone [9], glucocorticoid [10], follistatin-like 3 [11]), cytoskeleton proteins (e.g., microtubule actin crosslinking factor 1 [12], connexin 43 [13]), signaling pathways (e.g., Wnt signaling [14,15]) and microRNAs (miRNAs). Recent studies have discovered that miR-503-5p [22] and miR-103a [23] are sensitive to different mechanical stimuli when regulating osteogenic cell differentiation and bone formation. This review aims to provide an overview of the relationship between mechanosensitive miRNAs and bone formation, including mechanosensitive miRNAs and osteogenic differentiation; mechanosensitive miRNAs and osteoblast proliferation; and mechanosensitive miRNAs and bone formation
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
