Mechanochemical synthesis of some heterocyclic molecules using Sonogashira cross-coupling reaction and their anticancer activities

Abstract

A greener strategy for the synthesis of some functionalized heterocycles have been developed using Sonogashira cross-coupling reaction of furfural derived isoxazolidine and isoxazoline derivatives. This is a new approach for the functionalization of isoxazolidine and isoxazoline derivatives to modified heterocycles via cross-coupling reaction in solvent free ball-milling process. Since this kind of functionalization of cycloadducts to modified heterocycles via cross-coupling reaction are not known in literature, therefore, this approach will surely attract synthetic chemists to plan for this kind of reactions in organic synthesis. Significant anticancer activity of the new molecules added extra flavour in this synthesis. Simple reaction methodology, good to excellent yields and greener approaches are the important features noticed in this syntheses.