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Abstract
The physicochemical consequences of mechanical treatment of 5-nitro-8-hydroxyquinoline with natural polymers cellulose, pectin, and β-cyclodextrin were studied in order to improve its properties. It was found that particle sizes of the medicinal compound in the agglomerated mechanical-composite materials increased. The particle-size increase of the medicinal compound was avoided by adding a third component differing from 5-nitro-8-hydroxyquinoline by the acid-base properties and containing calcium carbonate.
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