Mechanochemical Grinding Diels–Alder Reaction: Highly Efficient and Rapid Access to Bi-, Tri-, and Tetracyclic Systems

Abstract

Grinding of various electron-deficient dienophiles with diverse dienes in a pestle and mortar for 1–15 minutes afforded the corresponding Diels–Alder adducts in quantitative yields under catalyst-free and solvent-free conditions, without the necessity for any purification steps.