Abstract
AbstractHerein, we report a minimalistic protocol for the solvent‐free, mechanochemical difluoromethylation of (thio)phenols and N‐heteroarenes using non‐ozone depleting chlorodifluoromethyl phenyl sulfone as a difluorocarbene source. This mechanochemical difluoromethylation features a short reaction time, excellent functional group tolerance, and compatibility with complex biologically active scaffolds.
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