Abstract
A form independent activation of zinc, concomitant generation of organozinc species and engagement in a Negishi cross‐coupling reaction via mechanochemical methods is reported. The reported method exhibits a broad substrate scope for both C(sp3)–C(sp2) and C(sp2)–C(sp2) couplings and is tolerant to many important functional groups. The method may offer broad reaching opportunities for the in situ generation organometallic compounds from base metals and their concomitant engagement in synthetic reactions via mechanochemical methods.
Highlights
A form independent activation of zinc, concomitant generation of organozinc species and engagement in a Negishi cross-coupling reaction via mechanochemical methods is reported
Whilst synthetic chemistry as a discipline has a good grasp on making molecules succumb to synthesis, focus in the modern era is centered upon achieving sustainable synthesis through reduced numbers of reaction steps, reduced quantities of waste, and milder reaction conditions.[1]
We report on the use of mechanochemistry as a technique to enable the form independent preparation of organozinc species, from the base metal zinc, and their engagement in mechanochemical Negishi cross-coupling reactions
Summary
A form independent activation of zinc, concomitant generation of organozinc species and engagement in a Negishi cross-coupling reaction via mechanochemical methods is reported.
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