Abstract
Many metal compounds are known to be useful in medicinal applications, and from these the many anticancer Pt(II) and Ru(II)/Ru(III) compounds are a special class, as they show a particular metal-ligand exchange behavior. In fact these compounds often do have ligand exchange kinetics in the same order of magnitude as the division of (tumor) cells, which make them suitable candidates to interfere with this process. The present chapter discusses this class of compounds with a focus on the mechanism of action of cisplatin and related Pt and Ru compounds. Even though we know that platinum antitumor drugs eventually end up on the DNA, it is not well understood how (fast) such compounds reach the DNA inside the cell nucleus, and how they are subsequently removed. The several types of Pt and Ru compounds that may reach and interact with DNA will be discussed, with an outlook for new drugs and other applications.
Published Version
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