Abstract
Vertebrate heart morphogenesis is a complex process that integrates different structures and cell types driven to interact by genetic and epigenetic factors. We have taken an interdisciplinary approach to studying heart formation by combining the power of molecular genetics with advanced optical imaging within living embryos. We have developed multiple transgenic quail lines and novel imaging methods that permit dynamic observation and manipulation of vascular development. Avian embryos are ideal for imaging due to the accessibility at all stages of development outside the vertebrate mother. These embryos also develop hearts with four chambers, allowing for comparative anatomy to study human hearts. Our primary goal is to analyze heart morphogenesis and determine the mechanisms of heart tube formation and the underlying features of heart tube looping.Grant Funding Source: NIH
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