Abstract
A new mode of solvent-assisted solid-to-solid polymorphic transformation of the first-formed and metastable γ-form into a stable, new α1-form, which occurs during crystallization from individual supersaturated EtOH solutions of a series of (±)-[2-[4-(2-hydroxy-3-phenoxypropoxy)phenylcarbamoyl]ethyl]trimethylammonium p-halobenzenesulfonates [(±)-1], has been found to cause an unusual symmetry-breaking enantiomeric resolution phenomenon called preferential enrichment. This polymorphic transition has been followed by the in situ attenuated total reflectance Fourier-transform infrared spectroscopy (ATR-FTIR) (ReactIR) measurement of the crystallization mixture and differential scanning calorimetry (DSC) analysis of the deposited crystals. The crystal structures with the α1-form have been solved either by X-ray crystallographic analysis of the single crystal or by the direct-space approach employing the Monte Carlo method with the subsequent Rietveld refinement from powder X-ray diffraction data of the powder ...
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
