Mechanisms Underlying Visuospatial Working Memory Impairments in Schizophrenia.

Abstract

Working memory deficits are observed in the vast majority of individuals diagnosed with schizophrenia and those at risk for the disorder. Working memory impairments are present during the prodromal stage and persist throughout the course of schizophrenia. Given the importance of cognition in functional outcome, working memory deficits are an important therapeutic target for schizophrenia. This chapter examines mechanisms underlying working memory deficits in schizophrenia, focusing on the roles of perception and attention in the encoding process. Lastly, we present a comprehensive discussion of neural oscillation and internal noise in the context of the etiology of working memory deficits in schizophrenia and introduce noninvasive treatment strategies that could improve encoding processes.