Abstract
Ceftriaxone is one of the first-line drugs for gonorrhea treatment.In vitro antimicrobial susceptibility studies have shown Neisseria gonorrhoeae strains with reduced susceptibility or resistance to ceftriaxone,which is mainly mediated by chromosomes.Current studies on ceftriaxone resistance are mainly focused on three aspects,i.e.,changes in antibiotic target sites affecting the combination of antibiotics and Neisseria gonorrhoeae,bacterial cell membrane porin changes resulting in decreased membrane permeability,and efflux system changes enhancing the bacterial efflux capacity,It has been demonstrated that penA,ponA,porB and mtrR genes are associated with Neisseria gonorrhoeae resistance. Key words: Neisseria gonorrhoeae; Ceftriaxone; Drug resistance
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