Mechanisms underlying the action of self-assembling short-peptide nano-fiber gel scaffold materials in the aesthetic repair of burn wounds

Abstract

To study the mechanism of self-assembling short-peptide nano-fiber gel scaffolds on the aesthetic repair of burns. RADA16-1 assembled short-peptide nano-fiber gel scaffold was prepared using the ultrasonic method. Twenty female SD rats were randomly divided into two groups. Burn model was established using the electrical machinery method. The wound surface of the rats in the experimental group was coated with RADA16-1 and that of the rats in the control group was coated with NaCl. The degree of wound healing, hair follicle growth, hair growth length, and expression of bFGF and EGF were compared between the two groups. RADA16-1 fibers were broken into short fibers under the ultrasonic environment and then reorganized into gels. The degree of wound healing, hair follicle growth, hair growth length, and expression of bFGF and EGF in the experimental group were better than those in the control group. The assembly of short peptide nano-fiber gel scaffolds can effectively repair burn wounds.