Abstract
This review provides an analysis of data on the mechanisms of the analgesic action of corticotropin-releasing factor (CRF) on somatic pain sensitivity. Experiments on rats addressed the involvement of opioid and glucocorticoid receptors and type 2 CRF receptors in mediating the analgesic effect induced by systemic administration of CRF. The results showed that the analgesic action of CRF may involve type 2 CRF receptors; CRF analgesia can appear in two forms: opioid-dependent and opioid-independent, whose development appears to be determined by the nature of the pain stimulus and the use of anesthesia. The opioid-dependent form of analgesia may be supported by glucocorticoid hormones.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
