Abstract
Earlier papers have described the selective uptake of the radioactive drug 2-methyl 6,7-ditritio-1, 4-naphthoquinol bis disodium phosphate into some human tumour cells in tissue culture. This work examines these results in greater detail. The kinetics of the uptake process into HEp/2 cells and its precise dependence on the experimental conditions are described. It is shown that an alkaline phosphatase (APase) is present on the surface of HEp/2 cells and that this is responsible for the uptake of label. L cells do not take up the radioactive label and are shown not to possess significant quantities of APase.
Highlights
Summary.-Earlier papers have described the selective uptake of the radioactive drug 2-methyl 6,7-ditritio-1, 4-naphthoquinol bis disodium phosphate into some human tumour cells in tissue culture
The object of the present work was to study the kinetics of this process and subsequently determine the mechanism of uptake of MNDP into HEp/2 and L cells
HEp/2 cells readily take up label and by 20 min have incorporated 45-60O%
Summary
Summary.-Earlier papers have described the selective uptake of the radioactive drug 2-methyl 6,7-ditritio-1, 4-naphthoquinol bis disodium phosphate into some human tumour cells in tissue culture. This work examines these results in greater detail. The kinetics of the uptake process into HEp/2 cells and its precise dependence on the experimental conditions are described. It is shown that an alkaline phosphatase (APase) is present on the surface of HEp/2 cells and that this is responsible for the uptake of label. The object of the present work was to study the kinetics of this process and subsequently determine the mechanism of uptake of MNDP into HEp/2 and L cells
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