Mechanisms of quorum sensing regulating antimicrobial resistance

Abstract

Antimicrobial resistance is a major threat to human health, so new strategies are urgently needed to impede antimicrobial resistance. Quorum sensing is an intracellular communication system that is activated to regulate downstream gene transcription when the population density reaches a threshold. Quorum sensing regulates drug resistance by altering biofilm formation and dispersion, efflux pump expression, and bacterial secretion systems, making it a promising target of overcoming antimicrobial resistance. To date, various quorum sensing inhibitors have been found to block quorum sensing by degrading signal molecules, interfering with the recognition and binding of signal molecules and receptors, and interrupting the synthesis of quorum sensing signals. Hence, quorum sensing inhibitors are expected to become a new way to control antimicrobial resistance.