Mechanisms of Light-induced Liposome Permeabilization.

Dyego Miranda,Jonathan F Lovell

doi:10.1002/btm2.10032

Abstract

Liposomes have been widely studied for drug delivery applications. The inclusion of photoactive molecules into liposomes opens the possibility of light‐controlled cargo release to enhance drug biodistribution or bioavailability at target sites. Membrane permeabilization induced by light can be an effective strategy for enhancing cargo delivery with spatial and temporal control, which holds potential for chemophototherapy approaches. Several diverse mechanisms have been reported including light‐induced oxidation, photocrosslinking, photoisomerization, photocleavage, and photothermal release. Here, we review selected recent reports of light‐triggered cargo release from liposomes.

Highlights

Liposomes have been used extensively for numerous applications, including as drug delivery systems
This study showed that both DOPC and cholesterol are oxidized by singlet oxygen resulting from excitation of porphyrin-phospholipid (PoP)
When the light power density required to cause a phase transition in the lipid bilayer was applied, liposomes encapsulating gold nanorods (GNRs) released approximately 57% of calcein, while almost 80% was released from liposomes embedded with indocyanine green (ICG)

Summary

| INTRODUCTION

Liposomes have been used extensively for numerous applications, including as drug delivery systems. Instead of membrane rupture, the photothermal effect induces a phase transition in the bilayer, which makes it leakier and leads to an increased cargo release.[72] The location of AuNPs or any other light absorber is variable and dependent on its hydrophobicity and charge They can be encapsulated within the liposomal core,[76,77] tethered to the membrane,[73,77,78] inserted within the bilayer,[72] free in liposome solution[77,79] or assembled as aggregates with liposomes (Figure 6).[80]. The approach of using ICG as a photothermal transducer was extended for triggered release of entrapped model drug cargos.[87]

| CONCLUSION

Findings

CONFLICT OF INTERESTS