Abstract
It was established in experiments on random-bred albino mice that the reduction of mortality of mice from sepsis and decrease of pro-inflammatory cytokines (TNF- , IL-1 , IL-6 ) concentrations in blood after acute intoxication with organophosphorus compounds (OPCs) is due to the implementation of the cholinergic antiinflammatory pathway: activation of muscarinic acetylcholine receptors m1 and 7n-acetylcholine receptors of the monocyte macrophage system. The anti-inflammatory effect after acute intoxication with OPCs is also associated with excitation of the sympathetic nervous system, 2 adrenergic receptors on T-lymphocytes, macrophages and monocytes and the subsequent reduction of pro-inflammatory cytokines in blood.
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