Mechanisms of hyperglycemic response to chlorpromazine administered into lateral ventricle in rats—II: Secretion of epinephrine from adrenal medulla

Abstract

An injection of chlorpromazine(CPZ) into the lateral ventricle caused hyperglycemia in intact rats, but not in adrenal-demedullated rats. However, the hyperglycemic response to CPZ was not blocked by hypophysectomy or pretreatment with dexamethasone. Beta-adrenergic blocking and ganglionic blocking both prevented CPZ-induced hyperglycemia. Furthermore, injection of CPZ did not potentiate the hyperglycemic response to exogenous epinephrine in demedullated rats. From these results, it is suggested that CPZ causes hyperglycemia mainly by the release of epinephrine from adrenal medulla stimulated by impulses from the central nervous system.