Abstract
It is demonstratedin vitro that X-ray contrast media cause the release of histamine from rabbit basophilic leukocytes in a dose-dependent manner at 37°C. They are arranged in the following order of decreasing ability to induce the release of histamine: bilignost∼triombrast>peritrast∼ultravist>melitrast∼omnipaque. The extent to which basophils in whole blood are degranulated during incubation with any of these media is about 40% higher than that upon incubation of isolated leukocytes with these media. The release of histamine under the action of the contrast media is a Ca2+-dependent process.
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