Mechanisms of drug resistance on nucleoside analogs treatment of hepatitis B virus infection

Jing Yang ,Shuling Zhang ,Lei Zhao

doi:10.3760/cma.j.issn.1673-4149.2011.04.019

Mechanisms of drug resistance on nucleoside analogs treatment of hepatitis B virus infection

Jing Yang , Shuling Zhang + Show 1 more

https://doi.org/10.3760/cma.j.issn.1673-4149.2011.04.019

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Publication Date: Aug 25, 2011

Affiliation: Huazhong University of Science and Technology

#Nucleoside Analogs #Nucleoside + Show 8 more

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Abstract

At present, nucleoside analogs have become the primary choice in the treatment of HBV infection, which are able to inhibit the replication of HBV effectively. Nevertheless, long-term therapy of nucleoside analogs leads to a resistant mutants. The resistance mechanisms of nucleoside analogs in the treatment of HBV infection are reviewed in this article. Key words: Hepatitis B virus; Nucleos(t)ide analogs; Resistance mechanism

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