Mechanisms of Disorders of the Characteristics of Fine Movements in Long-Term Hypokinesia

Abstract

The precision and electromyographic characteristics of single-joint voluntary movements of the human foot, of the programmed and tracking types, were studied, along with the characteristics of rhythmic activity of motor units before and during 120-day antiorthostatic hypokinesia. This latter was accompanied by significant decreases in the precision of the control system, evident as decreases in the number of discriminable force gradations, increases in the absolute and differential thresholds for movements of the programmed type, and sharp increases in the variability of integrated EMG traces from the working muscles during tracking movements. The direction and dynamics of changes in the activity of motor units at different stages of antiorthostatic hypokinesia were different: during the first 14-30 days (stage I), there was a sharp increase in the variability of interspike intervals and an increase in the extent of synchronization of motor unit activity; from day 30 onwards (stage II), there was a reproducible decrease in the duration of interspike intervals, along with disappearance of the synchronization of motor units, while the high level of variability of spike activity persisted. The results obtained here suggest that impairments of precision during stages I and II of antiorthostatic hypokinesia are different in nature and are associated with reflex responses to support unloading at stage I and with atrophic processes in muscles in stage II.