Mechanisms of COX-2 inhibitors combinated with cisplatin for lung cancer

Abstract

Selective COX-2 inhibitors can promote the apoptosis of tumor cells and block the growth of new blood vessels through the inhibition of ring oxidase, vascular endothelial growth factor, microvessel and so on. Research shows that COX-2 is overexpressed in vascular and endothelial cells of lung cancer, select COX-2 inhibitors to adjuvant chemotherapy, not only can directly inhibit the tumor proliferation, but also can reduce the adverse reaction of chemotherapy drugs, and enhance the curative effect. To investigate the effects of selective COX-2 inhibitors and cisplatin in lung cancer angiogenesis and its mechanism, will be a hope for the clinical treatment of tumor. Key words: Lung neoplasms; Vascular endothelial growth factors; Microvascular density; Tumor inhibitor