Mechanisms of Cell-Mediated Cytotoxicity II

Abstract

I. Non-Lymphocyte Cytotoxic Mechanisms.- Formation Of Protein Channels In Target Membranes.- Discussion.- Ige-Dependent Platelet Cytotoxicity Against Helminths.- Discussion.- Killing of Gram-Negative Bacteria by Neutrophils: Role of 02-Independent System in Intracellular Killing and Evidence Of 02-Dependent Extracellular Killing.- Discussion.- Abberant Oxygen Metabolism in Neoplastic Cells Injured by Cytotoxic Macrophages.- The Cell Biology of Tumor Cell Capture by Activated Macrophages.- Discussion.- Destructive Interactions Between Murine Macrophages, Tumor Cells, and Antibodies of the Igg2A Isotype.- II. Mechanistic Features Shared by CTL and NK Cells.- Reorientation of the Golgi Apparatus and the Microtubule Organizing Center: is it a Means to Polarize Cell-Mediated Cytotoxicity?.- Discussion.- Cytolytic T Cell Granules: Biochemical Properties and Functional Specificity.- Discussion.- The Role of Cytoplasmic Granules in Cytotoxicity by Large Granular Lymphocytes and Cytotoxic T Lymphocytes.- Discussion.- A Unified Theory for the Mechanism of the Lethal Hit by Cytotoxic T Lymphocytes (CTL) and Natural Killer (NK) Cells as Defined by Antisera Capable of Blocking the Lethal Hit Stage of Cytotoxicity.- Discussion.- Human Nk Resistant Tumor Cell Lysis is Effected by IL-2 Activated Killer Cells.- Discussion.- III. NK Cell Mediated Cytotoxicity.- Biochemical Characterization of Natural Killer Cytotoxic Factors.- Both NK Sensitive and Resistant Mycoplasma Free Cell Lines Stimulate Release of NKCF.- Discussion.- Studies of Human Natural Killer Cytotoxic Factor (NKCF): Characterization and Anlaysis of its Mode of Action.- Discussion.- An Investigation of the Role of Soluble Cytotoxic Factors and Reactive Oxygen Intermediates in Lysis by NK Cells.- Discussion.- Analysis of Sequential Substages Of the Natural Killer Cell Lethal Hit.- Discussion.- The Lipoxygenase Pathway in the Human Nk Cell System.- A Serine Proteinase as a "Trigger" For Human Natural Killer Lymphocyte-Mediated Cytolysis.- The Mechanism of Leukoregulin Enhancement of Target Cell Susceptibility to NK Cell Mediated Cytotoxicity in Humans.- IV. The Role of Membrane Components in CTL Function.- Lymphocyte Function-Associated Antigens: Regulation of Lymphocyte Adhesions in Vitro and Immunity in Vivo.- Discussion.- The Function of LFA-1 in Cell-Mediated Killing and Adhesion: Studies on Heritable LFA-1, Mac-1 Deficiency and on Lymphoid Cell Self-Aggregation.- Discussion.- Functional Interactions of LFA-1, T8 and Alloantigen Surface Structures in T-Cell Mediated Cytotoxicity.- Discussion.- Requirement for LYT-2/3 Molecules on Allospecific Cytolytic T Lymphocyte Clones is Dependent Upon Target Cell Antigen Density.- Discussion.- Functional Relationships of LYT-2 and LYT-3 Expression and T Cell Cytototoxicity: A New Model System.- The Role of the T3 Molecular Complex on Human T Lymphocyte-Mediated Cytotoxicity.- Discussion.- The Plasma Membrane 'Skeleton' of Tumor and Lymphoid Cells: a Role in Cell Lysis?.- p215 And p24: Two Membrane-Associated Proteins Expressed on Cloned Cytolytic T-Cells but Not on Cloned Helper T-Cells.- Mechansim of T-Dependent Cytotoxicity: Role of Papain-Sensitive Non CLASS I MHC Target Molecules and Expression of Target Antigen for Cytotoxicity.- Cell Contact Proteins in Antigen-Specific and Antigen-Nonspecific Cellular Cytotoxicity.- Discussion.- V. Post-Binding Events in the Cytotoxic Process.- Evidence for the Molecular Dissociation of Binding and Post-Binding Functions in Cytotoxic Lymphocytes.- Discussion.- Immune Cytolysis Viewed as a Stimulatory Process of the Target.- Discussion.- DNA Fragmentation in Targets of CTL: an Example of Programmed Cell Death in the Immune System.- Discussion.- Mechanism of Rapid Tumor Lysis by Human Adcc: Mediation by Monoclonal Antibodies and Fragmentation of Target Cell DNA.- Discussion.- Cell Surface Thiols, Methylation, and Complementlike Components are Involved in the Early Events of CML Whereas Proteases Participate in the Later,CaDependent Events.- Antigen/Mitogen Induced Cytolytic Activity and IL-2 Secretion in Memory-Like CTL Hybridomas.- Discussion.- Quantitative Models for The Kinetics of Cell-Mediated Cytotoxicity at the Single Cell Level.- Author Index.