Abstract
Activity of reactive oxygen species is elevated in diabetes mellitus and has been implicated in the destruction of cellular components. The toxic effect of reactive oxygen species was investigated by testing the effect of H 2O 2 on [Ca 2+] i in isolated islets of Langehans. H 2O 2 increased [Ca 2+] i in a dose-dependent manner, which was irreversible at high concentrations. The maximum effect of H 2O 2 on [Ca 2+] i was larger than those of KCl, glucose, ATP, carbachol and endothelin-1. The effect of H 2O 2 was only partially attenuated by removal of external Ca 2+ and by the in-organic Ca 2+ channel blocker nickel, but was not blocked by voltage-dependent or -independent Ca 2+ channel blockers nimodipine, nicardipine, SK&F 96365, econazole and lanthanum. H 2O 2, disrupted [Ca 2+] i homeostasis in islets by affecting both release and influx of Ca 2+ and causing dysfunction of Ca 2+ clearance systems and may contribute to the pathological process of diabetes.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
