Abstract
The purpose of this review is to understand why in individuals with Parkinson’s disease (PD) present with bradykinesia (i.e., slowness of movement). Bradykinesia reflects difficulties in motor plan, initiation and execution of movement. Clinically, bradykinesia is used to as a marker of disease severity, and is used to understand underlying mechanisms of motor disabilities in people with PD. In this review, we focus on the neurophysiology of bradykinesia by discussing the role of basal ganglia-cortical motor pathway. Moreover, we will discuss the neuromuscular characterization of bradykinesia in clinical and experimental studies in PD. Upon completing this review, human movement science scholars and practitioners should have a more comprehension understanding of the connections between the mechanisms of human movements and understanding neurophysiology of bradykinesia in PD.
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