Mechanisms of Body Weight Reduction by Black Tea Polyphenols.

Haibo Pan,Ying Gao,Youying Tu

doi:10.3390/molecules21121659

Haibo Pan, Ying Gao + Show 1 more

Open Access

https://doi.org/10.3390/molecules21121659

Copy DOI

Abstract

Obesity is one of the most common nutritional diseases worldwide. This disease causes health problems, such as dyslipidemia, hyperglycemia, hypertension and inflammation. There are drugs used to inhibit obesity. However, they have serious side effects outweighing their beneficial effects. Black tea, commonly referred to as “fermented tea”, has shown a positive effect on reducing body weight in animal models. Black tea polyphenols are the major components in black tea which reduce body weight. Black tea polyphenols are more effective than green tea polyphenols. Black tea polyphenols exert a positive effect on inhibiting obesity involving in two major mechanisms: (i) inhibiting lipid and saccharide digestion, absorption and intake, thus reducing calorie intake; and (ii) promoting lipid metabolism by activating AMP-activated protein kinase to attenuate lipogenesis and enhance lipolysis, and decreasing lipid accumulation by inhibiting the differentiation and proliferation of preadipocytes; (iii) blocking the pathological processes of obesity and comorbidities of obesity by reducing oxidative stress. Epidemiological studies of the health relevance between anti-obesity and black tea polyphenols consumption remain to be further investigated.

Highlights

Obesity is one of the most common nutritional diseases worldwide
Obesity arises from a metabolic imbalance in the organs and tissues of the human body between energy expenditure and energy intake which, in turn, leads to increasing fat accumulation in adipose tissue [5]
As the activity of lipase is inhibited by black tea polyphenols, much fewer hydrolysis products of fat will be absorbed into the plasma

Summary

Introduction

Obesity is one of the most common nutritional diseases worldwide. According to the World. Black tea polyphenols have been studied for their anti-obesity effects. There is increasing evidence to demonstrate that black tea polyphenols have an effect on preventing obesity. Numerous studies have reported the anti-obesity effect of black tea polyphenols in animals [17,18,19] and humans [20,21]. Black tea polyphenols dose-dependently inhibited the activity of pancreatic lipase in vitro with an IC50 of 0.254 mg/mL. It was reported that black tea extract and black tea polyphenols from black tea extract inhibited pancreatic lipase activity with an IC50 of 15.5 and 36.4 mg/mL in vitro (5). As the activity of lipase is inhibited by black tea polyphenols, much fewer hydrolysis products of fat will be absorbed into the plasma. To confirm exactly which components of tea are responsible for lipid excretion, both a comparison of the effects of green and black tea and an examination of the effects of individual components of black tea may be helpful

The Effect of Black Tea Polyphenols on Lipid Metabolism and Accumulation

The Effect of Black Tea Polyphenols on Saccharide Digestion and Absorption

Findings

The Anti-Oxidant Effect of Black Tea Polyphenols