Abstract
The recommendation that artemisinin combination therapy be used as first-line treatment for all cases of P. falciparum malaria [1] is being increasingly put into practice by national programmes. Prolonged parasite clearance times have been observed in artesunate-treated patients in Western Cambodia [2,3], but efforts to monitor and contain the problem of reduced artemisinin susceptibility are hampered by the fact that the mechanisms by which artemisinins kill parasites, and parasites develop resistance, remain shrouded in uncertainty.
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