Abstract

 
 
 In order to expand the theoretical base of targeted search for analeptics, the awakening and antihypoxic properties of Heterosides-21, Heterosides-31 (derivatives of sulfur and nitrogen containing heterocycles) were studied and their mechanisms of action were established. Sodium thiopental (42 mg/kg) was used to simulate suppression of the respiratory and vasomotor centers of the brain. Comparative drugs were the combined analeptic sulfocamphocaine (SCC) (20 mg/kg) and antihypoxant Piracetam (300 mg/kg).The results were obtained on the models of thiopental anesthesia and normobaric hypoxia with hypercapnia, the analysis of which allowed: to qualitatively and quantitatively assess the awakening, antihypoxic activity of the studied substances and classical preparations; their effect on the respiratory center of the brain and the behavioral responses of animals; theoretically substantiate, experimentally confirm and establish aerobic, anaerobic and detoxification mechanisms for the realization of effects in various conditions; to formulate the theoretical foundations of a targeted search for universal analeptics and antihypoxic drugs, to offer an instrumental and methodological complex for their experimental reproduction.
 
 
Highlights
The range of use of analeptic covers almost all spheres of urgent therapy for peace and wartime, as well as disaster medicine
Model of thiopental anesthesia (TPA), the study of their antihypoxic properties and mechanisms of action to create the theoretical foundations of a targeted search for analeptics
Antihypoxic properties were studied under conditions of normobaric hypoxia with hypercapnia (NBHH) [7,9] in 5 groups of mice (n = 9-10): 1st control pathology, the 2nd and the 3rd group were injected with freshly prepared aqueous solutions of Heterosides-21, Heterosides-31, 4th with SCC analeptic, 5th with Piracetam antihypoxant
Summary
The range of use of analeptic covers almost all spheres of urgent therapy for peace and wartime, as well as disaster medicine The paradox of this group of drugs is that with such a high demand, over the past 50 years, their arsenal in the global pharmaceutical market has not been replenished, but even reduced to 6 drugs (in Ukraine 3), which, due to their peculiarities and shortcomings, cannot meet the needs of resuscitation [1]. This is largely due to the lack of standardized methods for assessing their effectiveness, understanding of the mechanisms of action, as well as the theoretical foundations of targeted search. Model of thiopental anesthesia (TPA), the study of their antihypoxic properties and mechanisms of action to create the theoretical foundations of a targeted search for analeptics
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