Abstract
Survival after acute lung injury depends on prompt alveolar repair, a process frequently subverted by acute intraalveolar fibrosis in which exuberant growth of granulation tissue obliterates the alveolar air space. To gain insight into this process, we used immunohistochemical methods to examine the cellular populations present in the alveolus of lung specimens from 6 patients with acute lung injury. In addition to myofibroblasts, capillaries (factor VIII⊕) were present in the developing granulation tissue, indicating that angiogenesis was part of the pathologic process.
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