Abstract
Summary The use of radioactive (cobalt 60 -labeled) vitamin B 12 constitutes a new method for studying intestinal absorption of vitamin B 12 . This tool has been useful in elucidating mechanisms involved in the development of vitamin B 12 deficiency. Four distinct mechanisms can be identified. These are: a) deficiency of intrinsic factor, b) bacterial or parasitic interference with normal absorption of vitamin B 12 , c) defective absorptive capacity of the intestinal mucosa, and d) inadequate dietary intake of vitamin B 12 The pathologic physiology involved in each of these categories is discussed, and illustrative cases are presented.
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