Abstract
Acquired radioresistance in cancer of various types is a phenomenon all too common in the radiotherapist's experience. The lymphomas as a group appear to be among the most outstanding examples of human cancers which may exhibit this finding. To explain it, many theories are recorded in the literature; few experimentally established facts, however, are available. The purpose of this paper is to present negative data obtained by studying the effects of in vitro irradiation on a transplantable lymphoma in order to determine whether acquired radioresistance is a property of this tumor cell or the host. Methods The Gardner mouse lymphosarcoma 6C3HED was used throughout the experiment.2 The tumor was carried subcutaneously in young adult C3H mice obtained from the Roscoe B. Jackson Memorial Laboratory in Bar Harbor, Maine. All transplants were made under sterile conditions by the trocar implantation of one small (2 mm. in diameter) pellet of freshly excised tumor into the subcutaneous tissue of the lateral abdo...
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