Mechanisms for providing different reactivity to immobilization stress in male and female rats with different resistance to acute hypoxic hypoxia

Abstract

Attention of scientists of the world are study the features of increased resistance to hypoxia and chronic stress.The aim of the study was to trace the features of multidirectional correlations in the mechanisms of heart damage in high- and low-resistance to hypoxic hypoxia rats (HR, LR) in different models of immobilization stress.Material and methods of investigation. The experiments were performed on 144 outbred HR and LR aged 5.5-6 months, dividing into 3 groups – control and 2 with different model of immobilizing stress. Determine correlation between superoxide dismutase activity (SOD), catalase, GSH, glutathione peroxidase (GP), glutathione reductase (GR), conjugates diene and triene (DC, TC), Schiff bases (SB), TBA-active products, nitrite anion, in the blood – peroxidase activity (PAB), ceruloplasmin (CP), circulating immune complexes (CIC), oxidative modification of proteins.Results. In HR males rats in repeated every 24 hours stress, with increasing oxidative stress, has the positive correlation with the activity of antioxidant enzymes (SOD, catalase, CP), and in LR with the accumulation of CIC increases GSH. At the stress repeated every 72 hours, various mechanisms of adaptation are noted: in HR animals due to activation of catalase and SOD, in LR – mainly due to catalase and CP. In HR rats-female with stress, which is repeated every 24 hours, adaptation occurs due to activation of SOD and PAB, in LR with the accumulation of CIC – due to PAB and GR. When the stress is repeated every 72 hours, catalase and GH are mainly activated in HR female, in LR – SOD, PAB, CP.Conclusion. The experiments revealed significant correlations that indicate the individual characteristics of the adaptation of rats to immobilization stress, which depend on resistance to hypoxia and sex.