Mechanisms by which co-infections modify HIV-1 transmission

Grace C John-Stewart

doi:10.1186/1742-4690-5-s1-l4

Abstract

Women with HIV-1 are frequently co-infected with other pathogens that may influence transmission of HIV-1. Bacterial, helminth, and viral infections are prevalent in settings with high HIV-1 prevalence and may be associated with immune activation, increased HIV-1 replication and genital shedding. Discerning the contribution of co-infections to HIV-1 transmission is difficult because co-infections are more prevalent with advanced HIV-1, a scenario in which transmission is concurrently elevated due to increased systemic HIV-1 burden.

Highlights

Maternal chronic viral infections transmitted to infants: from mechanisms to prevention and care Meeting abstracts - A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/pdf/1742-4690-5-S1-info.pdf
Helminth, and viral infections are prevalent in settings with high HIV-1 prevalence and may be associated with immune activation, increased HIV-1 replication and genital shedding
Discerning the contribution of co-infections to HIV-1 transmission is difficult because co-infections are more prevalent with advanced HIV-1, a scenario in which transmission is concurrently elevated due to increased systemic HIV-1 burden

Summary

Introduction

Maternal chronic viral infections transmitted to infants: from mechanisms to prevention and care Meeting abstracts - A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/pdf/1742-4690-5-S1-info.pdf . Mechanisms by which co-infections modify HIV-1 transmission Women with HIV-1 are frequently co-infected with other pathogens that may influence transmission of HIV-1. Helminth, and viral infections are prevalent in settings with high HIV-1 prevalence and may be associated with immune activation, increased HIV-1 replication and genital shedding.

Results

Conclusion