Abstract
This chapter focuses on reviewing the physicochemical evidence for the mechanism(s) of drug permeation across oral mucosa. It aims to identify those biological and physicochemical parameters which determine the rate and extent of human oral mucosal drug absorption. In addition, the potential barriers that a drug encounters and the possible pathways through which it may traverse the oral mucosa are reviewed. Information pertaining to the mechanism of oral mucosal drug absorption for a given drug, the barrier(s) that it is likely to encounter and the pathway by which it traverses the oral mucosa may (i) provide the rationale for drug candidate selection, analogue synthesis or prodrug design and (ii) provide an insight into methods by which membrane permeability can be modified. Each of these factors may facilitate the optimisation and rational development of drugs and delivery systems for buccal delivery.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
