Mechanisms and Models

Abstract

Generally speaking, making models for unknown mechanisms is the creative process in science. Harre 1970, 40 INTRODUCTION: MECHANISMS AND MODELS Biologists often seek to discover mechanisms . Knowledge of biological mechanisms is valuable because descriptions of them often play the roles attributed to general scientific theories. They provide explanations of puzzling phenomena. They enable biologists to make predictions. They aid the design of experiments. They may explain domains of wide scope. They may make possible medical or biotechnological interventions for practical purposes. Especially in molecular biology, theories consist of sets of mechanism schemas, such as those for DNA replication and protein synthesis. Biologists use many types of models to represent and discover mechanisms: diagrammatic models, physical scale models, analogue models, model organisms, in vitro experimental systems, mathematical models, computer graphic and simulation models. Models represent and substitute for the thing modeled, while being easier to understand, manipulate, or study. Choice of an appropriate model depends on the problem to be solved using it. In medicine, animal models are often used when the goal is to understand disease mechanisms in humans. Molecular biologists use bacteria and viruses as models for mechanisms with domains of very wide scope, such as DNA replication.