Mechanism study of Herba Centipedae in the treatment of asthma based on network pharmacology

Abstract

Objective To explore the mechanism of Herba Centipedae in the treatment of asthma by screening out the active ingredients and targets, so as to construct a target-pathway network. Methods Based on TCMSP and Drugbank database to screen out active ingredients and corresponding targets of Herba Centipedae by using Cytoscape software to construct the interactive network among targets and the crosslink analysis to screen out the potential ingredients and targets of Herba Centipedae in the treatment of asthma . Finally, the information of signaling pathway was obtained after the GO enrichment analysis and KEGG pathway analysis were performed based on DAVID database, and then the ingredient-target-pathway network model was established. Results Expect to get 15 active ingredients, and 75 targets. And futher predict that the mechanism may relate to chemokine activity signaling pathway, extracellular space signaling pathway and TNF signaling pathway. Among the pathways, IL6, TNF, MAPK1, TP53, JUN genes may play a crucial role. Conclusions Based on the network of pharmacology, this study focuses on the characteristics of the multi-component, multi-target, and multi-pathway of Herba Centipedae in the treatment of asthma. Key words: Herba Centipedae; Asthma; Network pharmacology; Target; Signaling pathway