Abstract
Thiosemicarbazones (TSCs) has been shown as noncompetitive inhibitors of human Topoisomerase IIα (TopoIIα). Metal‐TSC complexes demonstrated higher activities than their ligands. Metal‐TSC was shown to bind on TopoIIα near the ATP binding pocket. Thus in the absence of ATP, metal‐TSC complexes can increase TopoIIα‐induced cleavage complexes, unlike other inhibitors of TopoIIα. The metal ions of TSC play a predominant role in the activity of TSCs. Cu‐TSC complexes are the most active ones compared to their Pd and Pt counterpart. In this study, we study the activity of metal‐TSC effects on TopoIIα in the presence and absence of ATP molecule and try to understand the mechanism how metal‐TSC interact with TopoIIα.This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.
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