Abstract
MECHANISM OF THE KETOGENIC EFFECT OF AMMONIUM CHLORIDE
Highlights
Liver Slices-Four experiments with liver slices from fed rats were in close agreement and completely confirmed the ketogenic effect of ammonium chloride as described by Edson [2]
It is recognized that the controlling mechanisms in the utilization of pyruvate in the liver of the intact animal will involve many controlling factors not operating in the reaction systems employed here
The ketogenic effect of added ammonium chloride in the rat liver slice has been confirmed and the phenomenon has been extended to the rat liver homogenate, supplemented with adenosinetriphosphate, magnesium, potassium, and phosphate
Summary
Pyruvic acid disappearance was followed by the direct method for total keto acids [19]. POTTER was always small enough to make corrections of little significance. p-
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