Abstract
The anticoagulant effect of squalene and retinoic acid was studied in adult male rats fed purified diets deficient in vitamin K. Both appear to inhibit absorption of vitamin K although possibly by different mechanisms. The requirement for vitamin K increased with a dietary increase of squalene but maximal action of retinoic acid was easily obtained and further ingestion of vitamin A did not affect prothrombin levels. The requirement for vitamin K in rats fed 0.5% squalene or 50 IU of retinoic acid/g of diet was about 9 µg/day which resembles the requirement in germfree rats. On this basis indigestible oils and retinoic acid may be useful agents for the production of “simple” vitamin K-deficiency in mammalian species.
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