Abstract
BackgroundThe tanshinones and phenolic acids in Salvia miltiorrhiza (also named Danshen) have been confirmed for the treatment of coronary heart disease (CHD), but the action mechanisms remain elusive.MethodsIn the current study, the co-expression protein interaction network (Ce-PIN) was used to illustrate the differences between the tanshinones and phenolic acids of Danshen in the treatment of CHD. By integrating the gene expression profile data and protein-protein interactions (PPIs) data, the Ce-PINs of tanshinones and phenolic acids were constructed. Then, the Ce-PINs were analyzed by gene ontology enrichment analyzed based on the optimal algorithm.ResultsIt turned out that Danshen is able to treat CHD by regulating the blood circulation, immune response and lipid metabolism. However, phenolic acids may regulate the blood circulation by Extracellular calcium-sensing receptor (CaSR), Endothelin-1 receptor (EDNRA), Endothelin-1 receptor (EDNRB), Kininogen-1 (KNG1), tanshinones may regulate the blood circulation by Guanylate cyclase soluble subunit alpha-1 (GUCY1A3) and Guanylate cyclase soluble subunit beta-1 (GUCY1B3). In addition, both the phenolic acids and tanshinones may regulate the immune response or inflammation by T-cell surface glycoprotein CD4 (CD4), Receptor-type tyrosine-protein phosphatase C (PTPRC).ConclusionThrough the same targets of the same biological process and different targets of the same biological process, the tanshinones and phenolic acids synergistically treat coronary heart disease.
Highlights
The tanshinones and phenolic acids in Salvia miltiorrhiza have been confirmed for the treatment of coronary heart disease (CHD), but the action mechanisms remain elusive
According to the World Health Organization, Coronary heart disease causes more than 700,000 deaths each year in China [2], which involves in thrombus formations [3], inflammation process [4], myocardial ischemia [5], etc
Salvianolic acid A, salvianolic acid B, protocatechuic aldehyde were chosen as the representative component of water-soluble compounds, and tanshinone I, tanshinone IIA, cryptotanshinone, dihydrotanshinone I were chosen as the representative compound of liposoluble compounds to study the mechanism of Danshen in treating coronary heart disease
Summary
The tanshinones and phenolic acids in Salvia miltiorrhiza ( named Danshen) have been confirmed for the treatment of coronary heart disease (CHD), but the action mechanisms remain elusive. The blood stasis medicine, has been used for treating the Danshen is the dry roots and rhizomes of Salvia miltiorrhiza Bge., which has the function of activating circulation and dispersing stasis. It has been widely used in clinics for the treatment of cardiovascular disease for hundreds of year [8,9,10].
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