Abstract
Human sodium-dependent multivitamin transporter (hSMVT) recognizes and transports a variety of vitamins such as biotin, lipoate, pantothenate, and I-, and the concentrative uptake of the vitamin substrates is driven by the Na+ gradient. Since humans cannot synthesize pantothenate or biotin, their intestinal absorption by hSMVT is essential for normal health and development. hSMVT has also been employed for the targeted delivery of prodrugs (e.g., biotinylated acyclovir) to improve their bioavailability and in the “triple vitamin” (pantothenate, biotin and lipoate) replacement therapy to treat a neurodegenerative disorder.
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