Abstract
The effect of solvent on the crystallization behavior of the polymorphs of 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazolecarboxylic acid (BPT) was investigated under rapid cooling. From methanol (MeOH) and ethanol (EtOH) solutions, only the solvated crystals of the D forms of methanol (D(MeOH)) and ethanol (D(EtOH)) crystallized. Both D forms are stable and have similar crystal structures. However, the solubility of the D(EtOH) form is 1.5 times higher than that of the D(MeOH) form. With the release of alcohol molecules, both D forms transformed to the C form with an increase in temperature for the DSC measurement. After that, the C form transformed to the A form via a melt-mediated mechanism. The release temperature of alcohol was higher for D(EtOH) than for D(MeOH). When the crystallization was performed in 1-propanol (1-PrOH) and 2-propanol (2-PrOH), the metastable A form preferentially crystallized. On the other hand, in acetonitrile (MeCN) solutions the stable C form was selectively obtained. Th...
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