Abstract
The sites of Streptococcus pneumoniae and Haemophilus influenzae infection differ in patients with respiratory infection. We investigated the in vivo mechanism of respiratory infection due to these organisms in mice, using an intranasal infection model.Growth factors such as hemin and NAD in the tracheal tissues and a growth inhibitor in the lung tissues were clearly involved in the development of H. influenzae infection. Chronic bronchial infection was caused by imparied mechanical clearance as well as by changes in the quantitative and qualitative function of neutrophilis. In S. pneumoniae infection, the decrease in the functional level of neutrophils was one of the factors in causing respiratory infection.
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Schedule a callMore From: Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases
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